CAS No.: 10236-47-2
Synonyms: 4',5,7-Trihydroxyflavanone 7-rhamnoglucoside / Naringenine-7-rhamnosidoglucoside
Molecular Formula: C27H32O14
Molecular Weight: 580.53
Naringin is an extract from grapefruit, and has been shown in studies to have a potent effect on the half-life of caffeine in the body (extending the rate at which caffeine is broken down). As such, naringin may effectively prolong the thermogenic activity of caffeine in the body so that it may continue to exert a fat burning effect for a longer period of time
Naringin belongs to the group of flavonoids. Pure naringin is a yellowish powder. Naringin is a conjugate of a sugar molecule with naringenin. The structure of naringin is very similar to that of hesperidin.
Distribution: Naringin is mainly found in grapefruits. It is the compound that gives grapefruit its typical bitter flavour.
Studies have shown that naringin interferes with enzymatic activity in the intestines and, thus, with the breakdown of certain drugs, resulting in higher blood levels of the drug. A number of drugs that are known to be affected by the naringin in grapefruit include calcium channel blockers, estrogen, sedatives, medications for high blood pressure, allergies, AIDS, and cholesterol-lowering drugs. Caffeine levels and effects of caffeine may also be extended by consuming grapefruit or grapefruit juice. While the effect of naringin on the metabolism of a drug can increase the drug's effectiveness, it can also result in dosages that are inadvertently too high. Therefore, it's best not to take any drugs with grapefruit juice unless the interaction with the drug is known. In addition, the effects of drinking grapefruit juice is cumulative, which means that if you drank a glass of grapefruit juice daily with your medication for a week, the drug interaction would be stronger at the end of the week than at the beginning Naringin can be used as an intermediate in the synthesis of many organic chemicals.
The best example is the sweeter neohesperidine dihydrochalcone.
Naringin is related to other flavanones known to have therapeutic action in influencing capillary permeability. For those pharmaceutical uses the better solubility of naringin in water is an advantage.