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Esculin

(CAS#: 531-75-9)

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Herb Source: Aesculus hippocastanum L. Cichorium intybus L. Hymenodictyon excelsum

Synonyms: Esculoside£¬Bicolorin£¬Enullachroma£¬Aesculin

Molecular Formula: C15H16O9

Molecular Weight: 340.28

Melting Point: 204¡æ-206¡æ£¨Hydrate£©

Solubility: Soluble in hot alcohol£¬methanol£¬pyridine£¬ethyl acetate and acetic acid (Hydrate)

Structural Class£ºCoumarin Appearance£ºNeedle

Pharmacology:
Esculin,Anti-inflammation, Anti-bacteria, Anti-cancer, Ease pain,Anti-arrhythmic, Anti-histaminic, Anti- cruor

Esculin is a glycosidecomposed of glucose and a dihydroxycoumarin compound. Esculin is a product of a coumarin derivative extracted from the bark of flowering ash (Fraxinus ornus). Esculin is used in the manufacturing of pharmaceuticals with venotonic, capillary- strengthening and antiphlogistic action similar to that of Vitamin P.

Esculin is a fluorescent dye that can be extracted from the leaves and bark of the horse chestnut tree. You'll need to shine a black (ultraviolet) light on the indicator to get the full effect. Esculin changes from colorless at pH 1.5 to fluorescent blue at pH 2.

The main pharmacological actions of esculin include capillary protection and the inhibition of enzymes such as hyaluronidase and collagenase. Esculin improved skin vasculature and is effective in the management of cellulitis.

The literature contains variable reports concerning the hydrolysis of esculin by members of the family Enterobacteriaceae and particularly Escherichia coli. We examined 113 strains of fresh clinical isolates of E. coli and assessed the ability of colonies in a population to hydrolyze esculin with and without preincubation in inducible substrates at 24, 48, and 72 h. The number of strains capable of fermenting salicin, a sugar with a beta-glucoside linkage like esculin, was studied under the same conditions. A strip test that measured the presence of the constitutive glucosidase was also performed with and without preincubation in inducible substrates. No E. coli strain was able to produce constitutive enzyme; preincubation in esculin and salicin resulted in an induction of the beta-glucosidase. The number of colonies able to hydrolyze esculin increased with time. Only those strains preincubated in esculin or salicin were able to produce a positive constitutive strip test. Because the beta-glucosidase of E. coli is inducible, one should employe, when using growth media, a light inoculum obtained by touching the top of a colony with a bacteriological wire and read the reaction between 18 and 24 h, or perform a rapid strip or spot test