Fentanyl
Lumiracoxib
Lercanidipin
Nilvadipine
Valganciclovi
Gemfibrozil
Levofloxacin
Topotecan
Amprenavir
Zileuton
Diclofenac
Cabergoline
Vancomycin
Anagrelide
Fludarabine
Lacidipine
Gatifloxacin
Saquinavir
Troglitazone
Voriconazole
Irbesartan
Indinavir
Glimepiride
Zaprinast
Duloxetine
Irinotecan
Amosulalol
Etoricoxib
Mevastatin
Flupentixol
Zonisamide
Anastrozole
Ceftiofur
Sotalol
Rosiglitazone
Isotretinoin
Tolterodine
Oxaliplatin
Vinorelbine
Paclitaxel
Flurocitabine
Enocitabine
Decitabine
Fluorouracil
Calcium Levofolinate
Tegafur
Triptorelin
Relenza
Colchicine
Amifostine
Salcalcitonin
Homoharringtonine
Fluvoxamine Maleate
Venlafaxine
Tarceva
Tamoxifen
Nelarabine
Clobetasol
Atorvastatin
Pioglitazone
Tramadol
Valsartan
Ramelteon
Topiramate
Pregabalin
Metformin Hhydrochloride
Meropenem
Ciprofloxacin

Zaleplon

For Souring from China, Please Contact Us

Recommend Site:

Description:

Zaleplon is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class. The chemical name of zaleplon is N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyla-cetamide. Its empirical formula is C17H15N5O, and its molecular weight is 305.34.

Zaleplon is a white to off-white powder that is practically insoluble in water and sparingly soluble in alcohol or propylene glycol. Its partition coefficient in octanol/water is constant (log PC = 1.23) over the pH range of 1 to 7.

The structural formula is shown below:

What is zaleplon?
? Zaleplon is in a class of drugs called sedative/ hypnotics or sleep medications. Zaleplon affects chemicals in your brain that may become unbalanced and cause insomnia .
? Zaleplon is used to treat insomnia. Zaleplon is for short-term use only--usually only a few days to two weeks. Longer-term use must be monitored closely by your doctor.
? Zaleplon may also be used for purposes other than those listed in this medication guide.
What are the possible side effects of zaleplon?
? If you experience any of the following serious side effects, stop taking zaleplon and seek emergency medical attention:
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, face, or tongue; or hives)
hallucinations (hearing or seeing things that are not real), abnormal behavior, or severe confusion.; or
suicidal thoughts.
? Other, less serious side effects may be more likely to occur. Continue to take zaleplon and talk to your doctor if you experience
day-time drowsiness;
dizziness or lightheadedness;
unsteadiness and/ or falls;
double vision or other vision problems;
agitation;
confusion;
headache;
nausea, vomiting, diarrhea, or abdominal pain;
depression;
muscle weakness;
tremor;
vivid or abnormal dreams; or
memory difficulties or amnesia.
? Zaleplon is habit forming. Stopping this medication suddenly can cause withdrawal effects such as mood changes, anxiety, and restlessness if you have taken it continuously for several weeks. Talk to your doctor about the safe use of this medication.
? Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect zaleplon?
? Before taking zaleplon, tell your doctor if you are taking any of the following medications:
rifampin (Rifadin, Rimactane);
phenytoin (Dilantin);
carbamazepine (Tegretol);
phenobarbital (Luminal, Solfoton); or
cimetidine (Tagamet, Tagamet HB).
? You may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
? Zaleplon may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, other sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.
? Drugs other than those listed here may also interact with zaleplon. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
What should I avoid while taking zaleplon?
? Use caution when driving, operating machinery, or performing other hazardous activities. Zaleplon will cause drowsiness and may cause dizziness. If you experience drowsiness or dizziness, avoid these activities. Zaleplon should be taken just before bedtime but you may experience some carryover effects (drowsiness, difficulty concentrating, memory loss) the next day.
? Do not drink alcohol while taking zaleplon. Alcohol will increase drowsiness and may increase dizziness while you are taking zaleplon, which could be dangerous.
? Zaleplon may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, other sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

OVERDOSAGE:

There is limited pre-marketing clinical experience with the effects of an overdosage of Zaleplon. Two cases of overdose were reported. One was the accidental ingestion by a 2 1/2 year old boy of 20 mg to 40 mg of zaleplon. The second was a 20 year old man who took 100 mg zaleplon plus 2.25 mg of triazolam. Both were treated and recovered uneventfully.

Recommended Treatment:

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Animal studies suggest that flumazenil is an antagonist to zaleplon. However, there is no pre-marketing clinical experience with the use of flumazenil as an antidote to a Zaleplon overdose. As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention.

DOSAGE AND ADMINISTRATION:

The dose of zaleplon should be individualized. The recommended dose of zaleplon for most nonelderly adults is 10 mg. For certain low weight individuals, 5 mg may be a sufficient dose. Although the risk of certain adverse events associated with the use of Sonata appears to be dose dependent, the 20 mg dose has been shown to be adequately tolerated and may be considered for the occasional patient who does not benefit from a trial of a lower dose. Doses above 20 mg have not been adequately evaluated and are not recommended.