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Ciprofloxacin

Moxifloxacin Hydrochloride

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(CAS: 186286-86-8)

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CAS: 186286-86-8

Chemical Name: 1-cyclopropyl-7-[(S,S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3 quinoline carboxylic acid

Formula: C21H24FN3O4.HCl

Structure:

What is the most important information I should know about moxifloxacin?

# Take all of the moxifloxacin that has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated.
# Do not take moxifloxacin without first talking to your doctor if you or any member of your family have a heart condition known as prolongation of the QT interval. Also, do not take moxifloxacin if you are being treated for heart rhythm disturbances with drugs such as quinidine (Cardioquin, Quinidex, Quinaglute, others), procainamide (Pronestyl, Procan SR, others), amiodarone (Cordarone, Pacerone, others), sotalol (Betapace), and others.
# Take moxifloxacin at least 4 hours before or 8 hours after antacids that contain magnesium, calcium, or aluminum (e.g., Tums, Rolaids, Maalox, others); the ulcer medicine sucralfate (Carafate); vitamin or mineral supplements that contain iron or zinc; or didanosine chewable/ buffered tablets or pediatric powder for oral solution (ddI, Videx, Videx Pediatric, others). These medicines may decrease the effectiveness of moxifloxacin.
# Use caution when driving, operating machinery, or performing other hazardous activities. Moxifloxacin may cause dizziness. If you experience dizziness, avoid these activities.

What is moxifloxacin?

# Moxifloxacin is an antibiotic in the class of drugs called fluoroquinolones. It fights bacteria in the body.
# Moxifloxacin is used to treat bacterial infections.
# Moxifloxacin may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking moxifloxacin?
# Do not take moxifloxacin without first talking to your doctor if you or any member of your family have a heart condition known as prolongation of the QT interval. Also, do not take moxifloxacin if you are being treated for heart rhythm disturbances with drugs such as quinidine (Cardioquin, Quinidex, Quinaglute, others), procainamide (Pronestyl, Procan SR, others), amiodarone (Cordarone, Pacerone, others), sotalol (Betapace), and others.
# Before taking moxifloxacin, tell your doctor if you have
, a low level of potassium in your blood;
, a slow heart rate;
, heart disease;
, liver disease; or
, epilepsy or another seizure disorder.
# You may not be able to take moxifloxacin or you may require a dosage adjustment or special monitoring during your treatment.
# Moxifloxacin is in the FDA pregnancy category C. This means that it is not known whether moxifloxacin will be harmful to an unborn baby. Do not take moxifloxacin without first talking to your doctor if you are pregnant or could become pregnant during treatment.
# It is unknown whether moxifloxacin passes into breast milk. Do not take moxifloxacin without first talking to your doctor if you are breast feeding a baby.
# Moxifloxacin is not approved for use by children younger than 18 years old.

How should I take moxifloxacin?

# Take moxifloxacin exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
# Take each oral dose with a full glass (8 ounces) of water. Drink plenty of fluid while taking moxifloxacin.
# Moxifloxacin can be taken with or without food.
# Moxifloxacin is usually taken once a day. Take each dose at the same time every day. Follow your doctor's instructions.
# Moxifloxacin may also be given by a healthcare provider by intravenous (IV) infusion.
# Take all of the moxifloxacin that has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated.
# Take moxifloxacin at least 4 hours before or 8 hours after antacids that contain magnesium, calcium, or aluminum (e.g., Tums, Rolaids, Maalox, others); the ulcer medicine sucralfate (Carafate); vitamin or mineral supplements that contain iron or zinc; or didanosine chewable/ buffered tablets or pediatric powder for oral solution (ddI, Videx, Videx Pediatric, others). These medicines may decrease the effectiveness of moxifloxacin.
# Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

# Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

# Seek emergency medical attention.
# Symptoms of a moxifloxacin overdose include seizures, poor coordination, tremors, sleepiness, vomiting and diarrhea.

What should I avoid while taking moxifloxacin?

# Avoid prolonged exposure to sunlight. Although it has not been reported with the use of moxifloxacin, other similar medicines have caused increased sensitivity of the skin to sunlight. Severe sunburn has resulted, even with minimal sun exposure. If exposure to the sun is unavoidable while taking moxifloxacin, wear protective clothing and use sunscreen. Call your doctor if you experience severe burning, redness, itching, rash, or swelling after exposure to the sun.
# Use caution when driving, operating machinery, or performing other hazardous activities. Moxifloxacin may cause dizziness. If you experience dizziness, avoid these activities.

What are the possible side effects of moxifloxacin?

# If you experience any of the following serious side effects, stop taking moxifloxacin and seek emergency medical attention or contact your doctor immediately:
, an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
, irregular or rapid heartbeats;
, fainting;
, seizures;
, liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue);
, muscle or joint pain; or
, skin rash.
# If you experience any of the following less serious side effects, continue taking moxifloxacin and talk to your doctor:
, nausea, vomiting, abdominal pain, or diarrhea;
, dizziness;
, headache; or
, increased sensitivity of the skin to sunlight.
# Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect moxifloxacin?

# Take moxifloxacin at least 4 hours before or 8 hours after antacids that contain magnesium, calcium, or aluminum (e.g., Tums, Rolaids, Maalox, others); the ulcer medicine sucralfate (Carafate); vitamin or mineral supplements that contain iron or zinc; or didanosine chewable/ buffered tablets or pediatric powder for oral solution (ddI, Videx, Videx Pediatric, others). These medicines may decrease the effectiveness of moxifloxacin.
# Do not take moxifloxacin without first talking to your doctor if you are taking any of the following drugs:
, the heart medicines quinidine (Cardioquin, Quinidex, Quinaglute, others), procainamide (Pronestyl, Procan SR, others), amiodarone (Cordarone, Pacerone, others), sotalol (Betapace), and others;
, a tricyclic antidepressant including amitriptyline (Elavil, Endep), amoxapine (Asendin), imipramine (Tofranil), nortriptyline (Pamelor), doxepin (Sinequan), and others;
, a phenothiazine including chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), thioridazine (Mellaril), and others;
, erythromycin (E-Mycin, Ery-Tab, E.E.S., others); or
, cisapride (Propulsid).
# Moxifloxacin and the drugs listed above may affect the rhythm of your heartbeats. You may not be able to take moxifloxacin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
# Before taking moxifloxacin, tell your doctor if you are taking:
, warfarin (Coumadin); or
, a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), naproxen (Aleve, Naprosyn, Anaprox), ketoprofen (Orudis KT, Orudis, Oruvail), and others.
# You may not be able to take moxifloxacin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
# Drugs other than those listed here may also interact with moxifloxacin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

What is the moxifloxacin recommend dosage?

The recommend dosage of moxifloxacin is 400 mg (orally or as an intravenous infusion) once every 24 hours. The duration of therapy depends on the type of infection as described below.

Infection * Daily Dose Duration
Acute Bacterial Sinusitis 400 mg 10 days
Acute Bacterial Exacerbation
of Chronic Bronchitis
400 mg 5 days
Community Acquired
Pneumonia
400 mg 7-14 days
Uncomplicated Skin and
Skin Structure Infections
400 mg 7 days
Complicated Skin and
Skin Structure Infections
400 mg 7-21 days
*due to the designated pathogens..

Oral doses of moxifloxacin should be administered at least 4 hours before or 8 hours after antacids containing magnesium or aluminum, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc, or VIDEX? (didanosine) chewable/buffered tablets or the pediatric powder for oral solution.

Where can I get more information about moxifloxacin?

# Your pharmacist has additional information about moxifloxacin written for health professionals that you may read.