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Aripiprazole

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(CAS: 129722-12-9)

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CAS: 129722-12-9

Chemical Name: 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril

Molecular Formula: C23H27Cl2N3O2

Structure of aripiprazole:

What is the most important information I should know about aripiprazole?

# Call your doctor immediately if you experience uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs; fever; muscle rigidity; sweating; irregular pulse; or fast or irregular heartbeats.
# Use caution when driving, operating machinery, or performing other hazardous activities. Aripiprazole may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
# Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.
# Avoid alcohol while taking aripiprazole. Alcohol may increase drowsiness and dizziness while taking aripiprazole.
# Avoid becoming overheated while taking aripiprazole. Aripiprazole may affect body temperature regulation. Use caution in hot weather and during exercise. Drink plenty of fluids.

What is aripiprazole?

# Aripiprazole is an antipsychotic medication. It works by changing the actions of chemicals in the brain.
# Aripiprazole is used to treat the symptoms of schizophrenia and acute bipolar mania.
# Aripiprazole may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking aripiprazole?

# Before taking aripiprazole, tell your doctor if you have
, liver disease;
, heart disease or other heart problems such as high blood pressure, angina, previous heart attack, or irregular heartbeats; or
, ever been diagnosed with breast cancer;
, diabetes;
, seizures or epilepsy.
# You may not be able to take aripiprazole, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
# Hyperglycemia (increased blood sugar) has been reported in patients treated with atypical antipsychotics including aripiprazole. Talk to your doctor if you experience any signs of hyperglycemia including excessive thirst, frequent urination, excessive hunger, or weakness.
# Each mL of aripiprazole oral solution contains 400mg of sucrose and 200mg of fructose.
# Aripiprazole is in the FDA pregnancy category C. This means that it is not known whether aripiprazole will be harmful to an unborn baby. Do not take aripiprazole without first talking to your doctor if you are pregnant or could become pregnant during treatment.
# It is not known whether aripiprazole passes into breast milk. Do not take aripiprazole without first talking to your doctor if you are breast-feeding a baby.

How should I take aripiprazole?

# Take aripiprazole exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you
# Take each dose with a full glass of water.
# Aripiprazole can be taken with or without food.
# Aripiprazole is usually taken once a day. Follow your doctor's instructions.
# It is important to take aripiprazole regularly to get the most benefit.
# Do not stop taking aripiprazole without first talking to your doctor, even if you are feeling well. Even after your symptoms improve, you may require continuous treatment for quite some time.
# Store aripiprazole tablets at room temperature away from moisture and heat.
# Aripiprazole oral solution should be stored in the refrigerator and can be used for up to 6 months after opening.

What happens if I miss a dose?

# Take the missed dose as soon as you remember, during the same day. If you do not remember until the next day, skip the missed dose and take only the regular daily dose. Do not take a double dose of the medication.

What happens if I overdose?

# Seek emergency medical attention.
# Symptoms of an aripiprazole overdose include drowsiness and vomiting.

What should I avoid while taking aripiprazole?

# Use caution when driving, operating machinery, or performing other hazardous activities. Aripiprazole may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
# Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.
# Avoid alcohol while taking aripiprazole. Alcohol may increase drowsiness and dizziness while taking aripiprazole.
# Avoid becoming overheated while taking aripiprazole. Aripiprazole may affect body temperature regulation. Use caution in hot weather and during exercise. Drink plenty of fluids.

What are the possible side effects of aripiprazole?

# Call your doctor immediately if you experience uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs; muscle spasms of the face or neck; severe restlessness or tremor; fever; muscle rigidity; sweating; irregular pulse; or fast or irregular heartbeats.
# If you experience any of the following serious side effects, stop taking aripiprazole and seek emergency medical attention or contact your doctor immediately:
, swelling of the throat; swelling of the lips, tongue, or face; or hives); or
, difficulty swallowing;
, frequent urination;
, increased thirst or hunger; or
, seizures.
# Other, less serious side effects may be more likely to occur. Continue to take aripiprazole and talk to your doctor if you experience
, headache;
, blurred vision;
, tremor or weakness;
, dizziness or drowsiness;
, nausea, vomiting, or constipation;
, difficulty sleeping; or
, weight gain.
# Hyperglycemia (increased blood sugar) has been reported in patients treated with atypical antipsychotics including aripiprazole. Talk to your doctor if you experience any signs of hyperglycemia including excessive thirst, frequent urination, excessive hunger, or weakness.
# Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect aripiprazole?

# Many drugs may affect the way that aripiprazole is metabolized ("broken down") in the body, leading to higher or lower than expected levels of the medication in the blood. Talk to your doctor before taking any other medicines during treatment with aripiprazole.
# Aripiprazole may increase the effects of medicines that are used to control high blood pressure. This could lead to very low blood pressure, dizziness, fainting, and other symptoms. Tell your doctor if you are taking a medication to lower blood pressure or to treat another heart condition.
# Aripiprazole may increase the effects of drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (medicines that treat insomnia), pain relievers, anxiety medicines, muscle relaxants, and any other drug that makes you feel sleepy or relaxed. Tell your doctor about all medicines that you are taking and do not take any medicine without first talking to your doctor.
# Drugs other than those listed here may also interact with aripiprazole. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines including vitamins, minerals, and herbal products.

What is the recommend dosage of aripiprazole?

The recommended starting and target dose for ABILIFY is 10 or 15 mg/day administered on a once-a-day schedule without regard to meals. ABILIFY has been systematically evaluated and shown to be effective in a dose range of 10 to 30 mg/day; however, doses higher than 10 or 15 mg/day, the lowest doses in these trials, were not more effective than 10 or 15 mg/day. Dosage increases should not be made before 2 weeks, the time needed to achieve steady state.

#Dosage in Special Populations
,Dosage adjustments are not routinely indicated on the ba-sis of age, gender, race, or renal or hepatic impairment sta-tus (see CLINICAL PHARMACOLOGY : Special Populations ).

,Dosage adjustment for patients taking aripiprazole concomitantly with potential CYP3A4 inhibitors: When concomitant administration of ketoconazole with aripiprazole occurs, aripiprazole dose should be reduced to one-half of the usual dose. When the CYP3A4 inhibitor is withdrawn from the combination therapy, aripiprazole dose should then be increased.

,Dosage adjustment for patients taking aripiprazole concomitantly with potential CYP2D6 inhibitors: When concomitant administration of potential CYP2D6 inhibitors such as quinidine, fluoxetine, or paroxetine with aripiprazole occurs, aripiprazole dose should be reduced at least to one-half of its normal dose. When the CYP2D6 inhibitor is withdrawn from the combination therapy, aripiprazole dose should then be increased.

,Dosage adjustment for patients taking potential CYP3A4 inducers: When a potential CYP3A4 inducer such as carbamazepine is added to aripiprazole therapy, the aripiprazole dose should be doubled (to 20 to 30 mg). Additional dose increases should be based on clinical evaluation. When carbamazepine is withdrawn from the combination therapy, the aripiprazole dose should be reduced to 10 to 15 mg.

Where can I get more information about aripiprazole?

# Your pharmacist has more information about aripiprazole written for health professionals that you may read.